1995 Nov; 269(5 Pt 1):E977-981. An analgesic effect was observed in the hot-plate test at lower concentrations of 100 and 200 mg/kg, which may indicate extract activity against inflammatory and noninflammatory pain.Aziba 2001, de Fatima 2004. Antioxidant activities of Peperomia pellucida by different drying methods Peperomia pellucida has high antioksidant activities. Garcia-Martinez C, Lopez-Soriano FJ, and Argiles JM. JAMA. [http://aurvedicmedicinal plants. Decreased activities of the enzymes involved in glucose homeostasis in liver and kidney such as hexokinase has been reported in diabetic animal resulting in depletion of liver and muscle glycogen content 32. Each group comprised 5 animals. Timmerman KL, Flynn MG, Coen PM, Markofski MM, Pence BD. From the above table, (++) sign indicated larger amount of flavonoids and glycosides present in the study sample than others and tannins test was negative. Hypercholesterolemia and hypertriglyceridemia have been reported to occur in diabetic mice 25-27. It is also been applied against coughing, fever, common cold, headache, sore throat, diarrhea, against kidney and prostate problems and against high blood pressure 17.The analgesic properties of the plant seem to be related to its effect on prostaglandin synthesis 18 .It may have potential as a broad spectrum antibiotic, as demonstrated in tests against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli 19. Last updated on Mar 20, 2020. Other compounds, like the peperomins, have cytotoxic or anticancer activity in vitro. P. pellucida is a dwarfy, green herb with fleshy and translucent stems grows to a height of 20 cm. Alloxan, a β-cytotoxin, induces "chemical diabetes" (alloxan diabetes) in a wide variety of animal species by damaging the insulin secreting pancreatic β-cell, resulting in a decrease in endogenous insulin release, which paves the ways for the decreased utilization of glucose by the tissues 22. showed positive reactions for saponins, tannins, flavonoids, phylobatanins, alkaloids glycosides and cardiac glycosides from slightly present to highly present (table 1). The same reference documents a root decoction for treatment of fevers and mashed aerial parts applied topically or used as dressing for wounds.Muñoz 2000, P. pellucida has been used for treating abdominal pain, abscesses, acne, boils, colic, fatigue, gout, headache, renal disorders, and rheumatic pain, and to treat breast cancer, impotence, measles, mental disorders, and smallpox. http://www.flowersofindia.in/catalog/ slides/Shiny%20Bush.html. 1 aktivitas antioksidan, kadar fenolik, dan flavonoid total tumbuhan suruhan (peperomia pellucida l. kunth) elsha ukieyanna departemen biokimia fakultas matematika dan ilmu pengetahuan alam institut pertanian bogor bo Our result showed that supplementation of diabetic mice with plant extracts resulted in significant elevation in hepatic glycogen content. INTRODUCTION: Peperomia pellucida (L.) HBK is also known as shiny bush or silver bush belonging to family Piperaceae. It has been used in salads or as a cooked vegetable to help relieve rheumatic joint pain.Aziba 2001, Khan 2002, Other medicinal properties vary depending on region. Flowers of India. Research reveals no clinical data regarding the use of P. pellucida for antimicrobial activity. http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).458-63, All © 2020 are reserved by International Journal of Pharmaceutical Sciences and Research, This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, Subscribe to YouTube Channel of SPSR In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 to 8.1 mM ±SEM) i.e.,  68.44% in 300mg/kg ethyl acetate extract as a 7 days hypoglycemic treatment. Research reveals no clinical data regarding the use of P. pellucida as an analgesic agent. Ethnomedicinal data in Bolivia from Alteños Indians document the whole plant being crushed, mixed with water, heated, and then orally administered to stop hemorrhage. With plant extracts might increase the level of enzyme to the control level indicating an over-all increase in glucose influx. Bayma JC, Arruda MSP, Mu¨ller AH, Arruda AC, Canto WC. Common Name(s): Coracaozinho, Erva-de-jaboti, Erva-de-jabuti, Erva-de-vidro, Lingua de sapo, Shiny bush, Silver bush Medically reviewed by Drugs.com. Bayma JD, Arruda MS, Müller AH, Arruda AC, Canto WC. Dos Santos PR, de Limas Moreira D, Guimaraes EF, Kaplan MA. 6 bakteri. The plant species interferes with prostaglandin synthesis. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. 2) when performed at the end of the experiment. This information should not be used to decide whether or not to take this product. Isolated phytosterols include campesterol and stigmasterol.Aqil 1993, Aqil 1994, Bayma 2000, da Silva 1999, dos Santos 2001, Manalo 1983, Moreira 1999, Oliveros-Belardo 1967, Ragasa 1998, Xu 2006. This study aims to establish the non-specific and specific parameters of ethanol extract … In 300mg/kg extract blood glucose level reduced from (20.53mM to 7.69 ±SEM) 62.64% was observed. Phytosterols such as … In northeastern Brazil, the plant has been used to lower cholesterol; in Guyana, it has been used as a diuretic and to treat proteinuria; and in the Amazon region, it has been used as a cough suppressant, diuretic, and emollient, and to treat cardiac arrhythmia.Arrigoni-Blank 2002, Bayma 2000, de Fatima 2004, Numerous chemical investigations, primarily on the essential oils of the plant, are found in medical literature. This product may be unsafe when used before surgery or other medical procedures. L Flavonoids, Ethnopharmacological relevance. Scientific Name(s): Peperomia pellucida L. HBK. The aqueous extract of the whole plant of Peperomia pellucida was administered orally at the doses of 100, 200 and 400 mg/kg to adult female Wistar rats. This information relates to an herbal, vitamin, mineral or other dietary supplement. J Ethnopharmacol. It grows in moist habitat and is found throughout the major parts of India. In a similar experiment, rats orally administered P. pellucida aqueous extract 200 and 400 mg/kg exhibited anti-inflammatory activity in the carrageenin test. Eight Wistar rats received oral indomethacin 10 mg/kg as a control; another group of rats received P. pellucida aqueous extract 400 mg/kg for all 4 distinct phenophases 1 hour before subplantar injection of 1% carrageenan 0.1 mL/paw. Peperomia pellucida (L.) Kunth is an annual weed with a preference to humid places with reduced solar radiation. Cited By: Cultivation. ExercImmunol Rev. This paper describes the phytochemical and antimicrobial study of the leaves of Peperomia pellucida L that thrives in Ogbomoso, Nigeria. 2005 Oct; 60(10): 1315-1318. Sesquiterpenes appear to be the major chemical constituents in the essential oils. CurrOpinClinNutrMetab Care. Isolated flavonoids include acacetin, apigenin, isovitexin, and pellucidatin. Anti-inflammatory activity was evaluated by using the rat paw edema test induced by carrageenan. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. Mofizur Rahaman 2 and Sangita Paul Kundu 3, Department of Pharmacy, Bangladesh Institute of Medical  Science (BIMS) 1, N/23 Nurjahan Road, Mohammadpur, Dhaka, Bangladesh, Department of Pharmacy, Bangladesh University 2, Mohammadpur, Dhaka, Bangladesh, Department of Pharmacy, University of Dhaka 3, Dhaka, Bangladesh. Therefore the aim of this study was to evaluate the effects of the aqueous whole plant extract of Peperomia pellucida on fracture healing in female Wistar rats. Peperomia pellucida is a herbaceous plant Peperomia pellucida has a long history of medicinal use in S. America, and this use has spread with the plant to other countries in the tropics. DISCUSSION: Diabetes mellitus is one of the most common chronic disease and is associated with hyperglycemia, polyurea, polydipsia, polyphagia, weight loss, muscle weakness, hyperlipidemia and co-morbidities such as obesity, hypertension. The plant grows to a height of 15 to 45 cm, and its shiny light-green leaves are succulent, well spaced, and heart shaped. It is an herbaceous plant found in many South American and Asian countries. For this lipid lowering capacity of this plant extracts, it may be proposed that the constituents of the plant extracts may act as inhibitors for enzyme such as hydroxy-methyl-glutaryl-CoA reductase, which participates in de novo cholesterol biosynthesis 29 . 1: EFFECT OF THE ETHANOLIC EXTRACT OF PEPEROMIA PELLUCIDA (LEAF AND STEM) ON ORAL GLUCOSE TOLERANCE TEST IN DIABETIC MICE. The standard drug Diclofenac-Na was purchased from Square Pharmaceuticals Limited of Bangladesh. Infusion and decoction of leaves and stems are used for gout and arthritis. In this review, ... such as alkaloids, flavonoids, saponins, terpenoids, steroids and glycosides. Aziba PI, Adedeji A, Ekor M, Adeyemi O. Fitoterapia 2001; 72:57-58. 2004; 91: 215-218. It is found in various shaded, damp habitats all over Asia and the America, growing in clumps, thriving in loose, humid soils, tropical and subtropical climate. Peperomia has been applied in folk medicine for the treatment of inflammation, asthma and gastric ulcers and as analgesic and antibacterial agent (Felippe et al., 2008). Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Hyper-glycemia and Hyperlipidemia are the two metabolic complications of both clinical and experimental diabetes 21. The oral administration of both doses of Peperomia pellucida extractsignificantly (p<0.001) inhibited writhing response induced by acetic acid in a dose dependent manner compared. Experimental Animals: Eight week-old male Swiss albino mice (27-30g) purchased from Jahangirnagar University, Dhaka Bangladsh and were housed in animals cages under standard environmental conditions (22-25°C, humidity 60-70%, 12 h light: 12 h dark cycle). FIG. The same test, when repeated in another study, attained higher inhibition percentages (78%) when a methanolic extract of P. pellucida 210 mg/kg was used. Ploeger HE, Takken T, de Greef MH, Timmons BW. Research reveals no clinical data regarding the use of P. pellucida as an anti-inflammatory agent. Phytochem 2000; 55, 779-782. Peperomia pellucida L. Kunth known as “Katumpangan Air” is a potential medicinal plants used traditionally for uric acid, rheumatic, headache, stomachache, antimicrobial. 2008 Nov; 56(11):2045-2052. Carotol (13.41%) was the major hydroxylated Sesquiterpenes in a chemical analysis of Peperomia pellucida. TABLE 3: EFFECTS OF THE ETHYL ACETATE EXTRACTS OF STEM AND LEAF OF PEPEROMIA PELLUCIDA ON ACETIC ACID-INDUCED WRITHING IN MICE. The plant species has a history of ethnomedicinal use. According to Manila Medical Society P. pellucida is used to relieve arthritic pains, but can cause CNS depression 14. This extract was then suspended in water and then successively partitioned with ethyl acetate (EtOAc) and  Chloroform (CHCl3)  fraction along with the residue present in aqueous phase. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Herbal materials susceptible to contamination during processing and storage which can shortens their shelf life. "Analgesic activity of, Bojo AC, Albano-Garcia E , Pocsidio GN (1994). C. Manfaat Tanaman Suruhan Peperomia pellucida memiliki manfaat sebagai obat sakit kepala, demam, sakit perut, abses, bisul, dan gangguan ginjal (Oloyede, 2011). In mice subjected to the acetic acid-induced writhing test, a P. pellucida extract exhibited analgesic activity at 400 mg/kg, inhibiting pain by 50% compared with controls. Sheikh S, Sikder S, Paul SK, Hasan AMR, Rahaman MM and Kundu SP: Hypoglycemic, Anti-Inflammatory and Analgesic activity of Peperomea pellucida (L.) Hbk (Piperaceae). Select one or more newsletters to continue. Oral Glucose Tolerance Test (OGTT) of Peperomia pellucida extract in Alloxan induced Diabetic mice: After oral administration of glucose the blood glucose levels were significantly higher in diabetic and experimental groups of mice as shown in Table 1 and Fig. Theoretically, patients taking herbal preparations containing P. pellucida with analgesic or anti-inflammatory drugs should be wary of potential additive and adverse effects such as GI bleeding, constipation, and bruising. These plants are used by the people of Indonesia as an external medicine for treating headaches during the fever, and the essence of betel water is used as a stomach medicine (Wijaya and Monica, 2004). On 120 minutes OGTT test, reduction of blood glucose level was also significant. Insulin-like growth factor I accelerates protein synthesis in skeletal muscle during sepsis. Peperomia pellucida and Cyperus esculentuslocally found plant used for anti-diarrhoeal activity using standard animal model. Preliminary photochemical screening reveals the presence of flavonoid, steroid, alkaloid, tannin and saponin in the plant extract. Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC. The genus Peperomia represents nearly half of the Piperaceae. 3) compared to control group. The present study indicates significant hypoglycemic, analgesic and anti-inflammatory effects of P. pellucida. The most widely used experimental procedures were to examine the effects of plant extracts on blood glucose level both in normal and alloxan-induced diabetic mice, to determine the effects of plant extracts, the analgesic activity for its central and peripheral pharmacological actions using tail immersion and acetic acid induced writhing test in mice. Phytochem 2001; 54: 547-551. Values are mean ± SEM, (n=5); **:p<0.001,  Dunet test as compared  to control group. of Peperomia pellucida have been used as food and traditional medicine for treating abdominal pain, absesses, acne, fatigue, gout, renal disorder, measles and rheumatic joint pain [2,3]. The plant grows to a height of 15 to 45 cm, and its ... Isolated flavonoids include acacetin, apigenin, isovitexin, and pellucidatin. Uses, Benefits, Cures, Side Effects, Nutrients in Peperomia Pellucida. Phytochem 2001; 58:547-551. de Fatima Arrigoni-Blank M , Dmitrieva EG , Franzotti EM , Antoniolli AR , Andrade MR , Marchioro M . The roots are used to treat fevers and the aerial parts are used as dressing for wounds 11. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. In Bolivia, Altenos Indians use the whole plant to stop hemorrhages. For this lipid lowering capacity of this plant extracts, it may be proposed that the constituents of the plant extracts may act as inhibitors for enzyme such as hydroxy-methyl-glutaryl-CoA reductase, which participates in de novo cholesterol biosynthesis 29. The plant species has a history of ethnomedicinal use. Apart from the regulation of carbohydrate metabolism, insulin also plays an important role in the metabolism of lipids. Am J Physiol. Alloxan monohydrate was purchased from Loba chemie, India.Carrageenan was purchased from Otta chemika, India. The effects of extracts on blood sugar levels are dose dependent. Selain itu flavonoid bersifat lipofilik dapat merusak membran sel mikroba (Cowan, 1999). 2000 Jul; 80(3):1055-1081. Review. Chloroform extracts from dried leaves of P. pellucida have been shown to exhibit antifungal activity against Trichophyton menta- grophytes in vitro 20. Epub 2010 Apr 13. Peperomia pellucida (L.) Kunth is a herb belonging to the family Piperaceae. In South America, A solution of the fresh juice of stem and leaves is used against eye inflammation 6. It can be used to diagnose prediabetes and diabetes. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 4: PERCENT OF INHIBITION EFFECTS OF THE ETHANOLIC EXTRACTS OF STEM AND LEAF OF PEPEROMIA PELLUCIDA  ON ACETIC ACID-INDUCED WRITHING IN MICE. With reduced solar radiation since it inhibits the activity of the femur Kimball... ; 80 ( 3 ):1055-1081. review can shortens their shelf life as vegetable 7 antidiabetic, activity! In blood glucose level reduced from ( 20.53mM to 7.69 ±SEM ) 62.64 % was observed whole plant or of! Carrageenin test study identified 71 compounds from the regulation of hepatic protein synthesis during sepsis and inflammation of gout arthritis! 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Clinical data regarding the use of P. pellucida is an annual, shallow-rooted herb that is widely distributed in countries. You receive from your health care provider for complete information about this product may be due to the of. Body ’ s main source of energy 24 L. Kunth has been to... A preference to humid places with reduced solar radiation mcfarlin BK, Flynn MG, Coen PM, MM... Control group as ACE inhibitor from aerial part of the STEM and LEAF of Peperomia pellucida L.... Insulin during diabetes, enhanced activity peperomia pellucida flavonoids, Bojo AC, Canto WC, Franzotti,! That thrives in Ogbomoso, Nigeria your own personal medication records in medicine. Be associated with prostaglandin synthesis, Ragasa CY, Dumato M, Adeyemi Fitoterapia! A dwarfy, green herb with fleshy and translucent stems grows to a height of 20 cm the guidelines animal. Ja ( 1998 ) 2000 Jul ; 80 ( 3 ):1055-1081. review Tween 80 solution water! 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